Meglumine CAS#6284-40-8

Enhances Drug Solubility: Meglumine is widely used as a counter ion to significantly improve the solubility of pharmaceutical compounds.
Improves Bioavailability: By optimizing drug formulation, it contributes to better absorption and bioavailability of active ingredients.
Amino Sugar Structure: As an amino sugar derived from sorbitol, it offers chemical stability and versatility in pharmaceutical applications.
Well-Defined Chemical Properties: Exhibits a pKa value of 9.6, providing predictable behavior in drug formulation and synthesis.

Contact Now E-Mail Telephone WhatsApp

Product Details

Product Description of Meglumine CAS# 6284-40-8

Selecting a suitable counter ion is crucial for enhancing the solubility and bioavailability of pharmaceutical compounds. Meglumine (N-methyl-D-glucosamine) is a widely used counter ion that effectively improves drug solubility. It is an amino sugar derived from sorbitol and has a pKa value of 9.6, making it valuable in pharmaceutical formulations.

Meglumine CAS#6284-40-8

Meglumine Chemical Properties

Melting point	129-131.5 °C (lit.)
alpha	-16.5 º (c=10, H2O, on dry sub)
Boiling point	331.88°C (rough estimate)
density	1.2669 (rough estimate)
refractive index	-16.5 ° (C=2, H2O)
RTECS	LZ4295770
storage temp.	2-8°C
solubility	H2O: 0.1 g/mL, clear, colorless
form	Crystalline Powder
pka	pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color	White to almost white
PH	11 (10g/l, H2O, 20℃)
optical activity	[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility	100 g/100 mL (25 ºC)
Sensitive	Air Sensitive & Hygroscopic
Merck	146078
BRN	385906
InChIKey	MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP	-3.370 (est)
NIST Chemistry Reference	N-methylglucamine(6284-40-8)
EPA Substance Registry System	Meglumine (6284-40-8)

Safety Information

Risk Statements	36/37/38
Safety Statements	24/25
WGK Germany	3
F	37917
Autoignition Temperature	~662 °F
TSCA	Yes
HS Code	29221980
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg