What is CAS#433711-95-6

CAS#433711-95-6 Introduction

(2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester (CAS#433711-95-6) is an important chemical intermediate widely used in the synthesis of pharmaceuticals and agrochemicals. Due to its unique properties and versatile applications, it is extensively utilized in the chemical industry. This article outlines its synthesis, properties, and applications in detail.

Synthesis of CAS#433711-95-6

The synthesis of (2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester involves the reaction of pyridine with tert-butyl chloroformate and sodium bromide. The reaction is carried out in an appropriate solvent such as dichloromethane or acetonitrile. The mixture is stirred at room temperature for several hours until completion. Afterward, the solvent is removed and the crude product is purified by column chromatography to obtain the final compound. The process generally yields a high-purity product with good efficiency.

Properties and Applications of CAS#433711-95-6

1. Properties:
(2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester is a white to off-white crystalline solid with a melting point of 94–97°C. It is slightly soluble in water but readily soluble in organic solvents such as methanol, ethanol, and acetone. The compound is stable under normal storage and handling conditions and does not decompose easily.

2. Applications:
This compound is a key intermediate in the synthesis of a wide range of pharmaceuticals and agrochemicals, including anti-inflammatory, anti-cancer, and antiviral drugs. It is also used in the production of insecticides and herbicides. Its unique chemical properties make it valuable in diverse industrial applications.

3. Toxicity:
The compound is considered to have relatively low toxicity and is not classified as a hazardous substance by major regulatory authorities. However, standard chemical handling and storage precautions should always be observed.

Conclusion

(2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester is a valuable intermediate in pharmaceutical and agrochemical synthesis. It offers reliable synthesis routes, high purity output, and broad application potential. As global demand for pharmaceuticals and agrochemicals continues to grow, its importance in the chemical industry is expected to further increase.