Product Description of Rutin CAS# 153-18-4
Rutin is the rutin glycoside of the flavonol compound quercetin, a plant-derived flavonoid. It is naturally found in rue, tartary buckwheat, Sophora buds, catalpa leaves, tomato stems, leaves, and seed shells. Dry buckwheat contains approximately 3% rutin, while plants such as jujube, hawthorn, ginkgo, wolfberry, motherwort, bupleurum, prunella vulgaris, aloe, and Gynostemma pentaphyllum also contain this compound. In the flower buds of Sophora japonica L., the rutin content can exceed 20%, making it the primary raw material for pharmaceutical extraction in China.
Rutin is sensitive to strong acidic or alkaline conditions and can decompose upon contact with water. It is unstable in color under alkaline conditions but exhibits significant antioxidant activity. In ethanol, it can enhance the light stability of pigment preparations and prevent the gradual loss or alteration of fragrance. When combined with vitamin E, its antioxidant capacity is further improved.
![Rutin CAS#153-18-4]( "Rutin CAS#153-18-4")
Rutin Chemical Properties
Melting point | 195 °C (dec.)(lit.) |
alpha | D23 +13.82° (ethanol); D23 -39.43° (pyridine) |
Boiling point | 576.13°C (rough estimate) |
density | 1.3881 (rough estimate) |
refractive index | 1.7650 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | pyridine: 50 mg/mL |
Colour Index | 75730 |
form | powder |
pka | 6.17±0.40(Predicted) |
color | yellow to green |
Water Solubility | 12.5 g/100 mL |
Merck | 8304 |
Stability: | Hygroscopic |
LogP | -2.020 (est) |
CAS DataBase Reference | 153-18-4(CAS DataBase Reference) |
NIST Chemistry Reference | Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4) |
EPA Substance Registry System | Rutin (153-18-4) |
Safety Information
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 3 |
RTECS | VM2975000 |
F | 8 |
HS Code | 29381000 |
Toxicity | LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison) |
![Rutin CAS#153-18-4]( "Rutin CAS#153-18-4")
Product Application of Rutin CAS# 153-18-4
Food Additive and Nutritional Supplement
Rutin is used as a food coloring agent (e.g., lemon yellow), an antioxidant, and a nutritional supplement. It is mainly applied in cold drinks, beverages, pastries, processed meat products, and processed aquatic products.
Vitamin and Pharmaceutical Applications
Exhibits the ability to reduce capillary permeability and fragility, helping to maintain and restore normal capillary elasticity. It is used for the prevention and treatment of hypertensive cerebral hemorrhage, diabetic retinal hemorrhage, and hemorrhagic purpura. Additionally, it serves as a food antioxidant and pigment.
Cardiovascular and Liver Support
Provides anti-inflammatory effects and vitamin P-like benefits, maintaining blood vessel resistance, reducing permeability and fragility. It also promotes lipid reduction in fatty liver, with enhanced effects when combined with glutathione.
Additional Bioactive Properties
Shows antiviral activity and can inhibit aldose reductase, contributing to broader therapeutic and protective applications.
![Rutin CAS#153-18-4]( "Rutin CAS#153-18-4")
